SRP6548
ApoJ/Clusterin human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
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Synonym(s):
AAG4, CLI, Clusterin Apolipoprotein J, KUB1, MGC24903, SGP-2, SGP2, TRPM2
UNSPSC Code:
12352202
NACRES:
NA.32
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General description
Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
Physical form
Lyophilized from 2 mg/mL solution of ApoJ in 25 mM Na2HPO4 and 100 mM NaCl (pH 7.5).
Reconstitution
Reconstitute in dH2O to a working concentration of 0.5 mg/mL and let the lyophilized pellet dissolve completely.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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