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Safety Information

SRP6537

Sigma-Aldrich

Lipocalin-2/LCN2 from mouse

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym(s):

24p3, MSFI, NGAL, Neutrophil Gelatinase-associated Lipocalin, Oncogene 24p3, Siderocalin

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

mouse

recombinant

expressed in HEK 293 cells

Assay

≥90% (SDS-PAGE)

form

liquid

mol wt

monomer ~250 kDa (Mouse lipocalin-2 aa 1-200 is fused at the C-terminus to a FLAG0174-tag.)

packaging

pkg of 10 and 50 μg

impurities

<0.1 EU/μg endotoxin (LAL test)

UniProt accession no.

P11672

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... LCN2(16819)

General description

LCN2 (lipocalin-2), a secreted glycoprotein is an adipokine. It is expressed in various cells like respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells and cardiomyocytes. The gene LCN2 is located on human chromosome 9q34.
Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF α) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.

Biochem/physiol Actions

LCN2 (lipocalin-2) has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. Polymorphisms in the expression of LCN2 are associated with many cancers such as breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder and kidney cancers.

Physical form

0.2 μm-filtered solution in PBS.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Wu B, et al.
Scientific Reports, 4, 5403-5403 (2014)
Mengistu Lemecha et al.
Molecular metabolism, 66, 101612-101612 (2022-10-16)
Adipose tissue is the largest endocrine organ. When activated by cancer cells, adipocytes secrete adipocytokines and release fatty acids, which are then transferred to cancer cells and used for structural and biochemical support. How this metabolic symbiosis between cancer cells
The pancreatic expression database: recent extensions and updates.
Dayem Ullah AZ, et al.
Nucleic Acids Research, 42(D1), D944-D949 (2013)
Plasma levels of neutrophil gelatinase-associated lipocalin in children with heart failure
Tawfeek MS, et al.
Therapeutic Advances in Cardiovascular Disease, 10(1), 30-36 (2016)
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans
Catalan V, et al.
Journal of Molecular Medicine, 87(8), 803-813 (2009)

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