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General description
Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.
Biochem/physiol Actions
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
Physical form
Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
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Minor Role of Plasminogen in Complement Activation on Cell Surfaces.
Hyvarinen S and Jokiranta TS
PLoS ONE, 10, e0143707-e0143707 (2015)
Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta.
Odekon LE, et al.
Journal of Cellular Physiology, 158, 398-407 (1994)
Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices.
Davis GE, et al.
Journal of Cell Science, 114, 917-930 (2001)
Molecular characterisation of the human apo (a)-plasminogen gene family clustered on the telomeric region of chromosome 6 (6q26?27).
Magnaghi P, et al.
Human Molecular Genetics, 3(3), 437-442 (1994)
Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo.
Inoue K, et al.
The Journal of Biological Chemistry, 274, 27069-27075 (1999)
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