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SRP6517

Sigma-Aldrich

Alpha 2HS Glycoprotein from human plasma

≥90% (SDS-PAGE)

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Synonym(s):
Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

49 kDa

packaging

pkg of 1 mg

UniProt accession no.

P02765

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... AHSG(197)

General description

AHSG (α2-HS glycoprotein), or fetuin-A, is a predominant serum glycoprotein with a molecular weight of 64kDa, and is produced and secreted primarily by hepatic cells. It is highly present in the extracellular matrix (ECM) of the bone.

Biochem/physiol Actions

AHSG (α2-HS glycoprotein) is a multifunctional protein, and acts as an inhibitor of insulin receptor tyrosine kinase. It is involved in insulin resistance by promoting adipose tissue inflammation by functioning as a ligand for Toll-like receptor 4. Therefore, it is linked to the type 2 diabetes. This protein plays a crucial role in the prevention of extracellular calcification. This protein is a candidate plasma biomarker for early hypopharyngeal squamous cell carcinoma (HSCC) diagnosis. It is also a negative acute-phase protein, and its serum levels reduce drastically following surgeries, trauma, burns, and severe inflammation. Studies in Chinese populations show the serum levels of this protein is linked with fatty liver index (FLI), alanine aminotransferance (ALT), and aspartate aminotransferance (AST), which are early indicators of nonalcoholic fatty liver disease (NAFLD).

Physical form

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

高风险级别生物产品--人源产品

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Serum Fetuin-A Associated With Fatty Liver Index, Early Indicator of Nonalcoholic Fatty Liver Disease: A Strobe-Compliant Article.
Huang Y et al
Medicine, 94(39), e1517-e1517 (2015)
Allelic Imbalance of mRNA Associated with a2-HS Glycoprotein (Fetuin-A) Polymorphism.
Inaoka Y et al
Disease Markers, 2015, 865053-865053 (2015)
Chelsea Miller et al.
Journal of biomedical materials research. Part A, 111(8), 1096-1109 (2023-01-03)
Surface modifications can be applied to biomaterials to alter the various surface properties that influence protein-material interactions and the cellular response. The plasma protein fetuin-A has been found to adsorb to many biomaterials but details of its interactions with polydimethylsiloxane
Wen-Dong Tian et al.
International journal of clinical and experimental pathology, 8(8), 9021-9031 (2015-10-16)
Hypopharyngeal squamous cell carcinoma (HSCC) has very poor prognosis compared with other head and neck squamous cell carcinomas. Late-stage diagnosis of HSCC increases mortality. Therefore, more effective biomarkers for early diagnosis of HSCC are necessary. Unfortunately, appropriate biomarkers for clinical

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