SRP6368
TREM2 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
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Synonym(s):
Trem2a, Trem2b, Trem2c, Triggering receptor expressed on myeloid cells 2
UNSPSC Code:
12352200
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
liquid
mol wt
20.4 kDa (181 aa, 19-161 aa + His Tag)
packaging
pkg of 50 μg
concentration
0.25 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TREM2(54209)
General description
TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Physical form
0.25 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Hyuk Sung Kwon et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 73, 215-218 (2020-02-19)
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic
Qian Zhai et al.
Anesthesiology, 127(1), 98-110 (2017-04-12)
Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days
Francesca Cignarella et al.
Acta neuropathologica, 140(4), 513-534 (2020-08-11)
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2
Dennis Kristopher Berner et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6675-6687 (2020-04-03)
The triggering receptor expressed on myeloid cells 2 (TREM2) is a multifunctional surface protein that affects survival, migration, and phagocytic capacity of myeloid cells. Soluble TREM2 levels were found to be increased in early stages of sporadic and familial Alzheimer's
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