SRP6315
Alpha 2 Macroglobulin, Fast Form from human plasma
≥95% (SDS-PAGE)
Synonym(s):
A2M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, FWP007
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Product Name
Alpha 2 Macroglobulin, Fast Form from human plasma, ≥95% (SDS-PAGE)
biological source
human
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
725 kDa (Homotetramer Subunit size: 180 kDa)
packaging
pkg of 1 mg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... A2M(2)
Biochem/physiol Actions
α 2 macroglobulin (A2M) functions as a broad-spectrum protease-binding protein. In addition, it acts as an irreversible inhibitor of a variety of proteinases. A2M expressed in the brain interacts with multiple extracellular ligands and is interiorized by neurons and astrocytes. In the brain of Alzheimer′s disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M interacts with soluble β-amyloid and facilitates its degradation.
General description
α 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer′s disease and spongiform encephalopathy.
α 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg/100 mL in men and 290 mg/100 mL in women. It is produced by the liver and is a major component of the α-2 band in protein electrophoresis. It has a molecular weight of 800,000Da.
Physical form
Lyophilized from 100 mM Na Phosphate, pH 7.2.
Preparation Note
In water or aqueous buffer
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Interleukin-6 and α2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.
Bauer, Joachim, et al.
Febs Letters, 285(1), 111-114 (1991)
The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.
Barrett A J and Phyllis M S
The Biochemical Journal, 133(4), 709-724 (1973)
Loic Auderset et al.
Frontiers in cell and developmental biology, 8, 564351-564351 (2020-12-08)
Low-density lipoprotein receptor-related protein 1 (LRP1) is a large, endocytic cell surface receptor that is highly expressed by oligodendrocyte progenitor cells (OPCs) and LRP1 expression is rapidly downregulated as OPCs differentiate into oligodendrocytes (OLs). We report that the conditional deletion
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