SRP6241
VAP-1 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
Synonym(s):
AOC3, Copper Amine Oxidase, HPAO, Membrane Primary Amine Oxidase, SSAO, Vascular Adhesion Protein-1
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human
Recombinant:
expressed in CHO cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
~80 kDa
Impurities:
<1 EU/μg endotoxin (LAL test)
biological source
human
recombinant
expressed in CHO cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
~80 kDa
packaging
pkg of 10 μg, pkg of 50 μg
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VAP1(8639)
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General description
VAP-1 (vascular adhesion protein 1) is also called as semicarbazide-sensitive amine oxidase. The VAP-1 gene is mapped to human chromosome 17q21.31.
VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. It is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. VAP-1 can catalyze the oxidative deamination of low molecular weight amines, and plays an important role in the migration of lymphocytes to inflamed tissue. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor.
Biochem/physiol Actions
VAP-1 (vascular adhesion protein 1) catalyzes an oxygen-dependent reaction involving the conversion of primary amines to aldehyde, ammonia and hydrogen peroxide. Overexpression of VAP-1 is observed in chronic inflammatory diseases such as chronic renal failure, diabetesand autoimmune disorders. VAP-1 mediates the interaction between leukocytes and endothelium in response to inflammation.
Physical form
Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.8.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Find documentation for the products that you have recently purchased in the Document Library.
Role of vascular adhesion protein-1 in patients with alopecia areata
El-Taweel AEAI, et al.
Beneficial Microbes, 35(1), 28-28 (2018)
Correlation of serum vascular adhesion protein-1 with airflow limitation and quality of life in stable chronic obstructive pulmonary disease
Amani M, et al.
Respiratory Medicine, 132, 149-153 (2017)
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