SRP6187
Eosinophil Peroxidase human
≥95% (SDS-PAGE)
Synonym(s):
EPER, EPO, EPP
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
biological source
human
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
70.5 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
Gene Information
human ... EPX(8288)
shipped in
wet ice
storage temp.
−20°C
General description
Native, human eosinophil peroxidase is a secreted hemoprotein that catalyzes oxidations of various substrates by hydrogen peroxide. Together with other leukocyte-derived enzymes, such as Myeloperoxidase, EPO plays an important role in the pathogenesis of asthma by mediating oxidative events that lead to the production of ROS (reactive oxygen species) and RNS (reactive nitrogen species).
Physical form
Lyophilized from 20 mM NaH2PO4, pH 7.5, and 150 mM NaCI.
Preparation Note
Reconstitute in deionized H₂O. Aliquot and store at –20°C. Avoid freeze-thaw cycles.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jorge Sánchez et al.
Allergy, asthma & immunology research, 13(5), 746-761 (2021-09-07)
Eosinophils are frequently found in atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) that release eosinophil peroxidase (EPX) and eosinophil cationic protein (ECP). Continuous exposure to these proteins could trigger an autoimmune response which may contribute to the pathogenesis and
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