SRP6165
M-CSF human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(s):
CSF-1, Lanimostim, MGC31930, Macrophage colony stimulating factor 1
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
(35 and 40 kDa, homodimer, glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CSF1(1435)
General description
Granulocyte/macrophage colony-stimulating factors (MCSFs) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
Biochem/physiol Actions
The gene encoding macrophage colony-stimulating factor (MCSF) is located on human chromosome 1p13.3. It is a glycosylated polypeptide which exists as a homodimer.
Physical form
Lyophilized from a PBS solution.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
Albagha OM
Nature Genetics, 42(6), 520-524 (2010)
Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.
Rettenmier CW
Molecular and Cellular Biology, 7(7), 2378-2387 (1987)
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