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Key Documents

Safety Information

SRP6164

Sigma-Aldrich

G-CSF human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(s):

CSF-3, Filgrastim, GM-CSF beta, MGI-1G, Pluripoietin

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About This Item

UNSPSC Code:
12352202

biological source

human

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

form

lyophilized

potency

0.02-0.08 ng/mL

mol wt

21-25 kDa (monomer, glycosylated)

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

NCBI accession no.

P09919

UniProt accession no.

P09919

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CSF3(1440)

General description

Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a cytokine. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for the GCSF gene. Human and murine G-CSF is cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17.

Biochem/physiol Actions

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation and function of two related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Granulocyte colony stimulating factor (G-CSF) controls the production, differentiation and function of granulocytes. It has been shown to have a role in bone repair in animal models. G-CSF has been clinically approved for neutropenia treatment.

Physical form

Lyophilized from a PBS solution.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
6D24L64530
5F14L64530
4J19L64530
9E026453

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Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Kim JS
Oncology Reports, 34(1), 147-154 (2015)
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
Swift A
British Journal of Cancer, 71(5), 995-998 (1995)
Effect of Granulocyte-Colony Stimulating Factor on Endothelial Cells and Osteoblasts.
Liu XL
BioMed Research International, 8485721-8485721 (2016)
Lian Cai et al.
PloS one, 15(3), e0230247-e0230247 (2020-03-18)
Granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine, belongs to the hematopoietic growth factor family. Recent studies have reported that G-CSF is a predictive biomarker of oocyte and embryo developmental competence in humans. The aim of our study was to determine
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
Cytokine, 78, 69-78 (2016)
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