SRP6164
G-CSF human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
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Synonym(s):
CSF-3, Filgrastim, GM-CSF beta, MGI-1G, Pluripoietin
UNSPSC Code:
12352202
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biological source
human
recombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
form
lyophilized
potency
0.02-0.08 ng/mL
mol wt
21-25 kDa (monomer, glycosylated)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CSF3(1440)
General description
Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a cytokine. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for the GCSF gene. Human and murine G-CSF is cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17.
Biochem/physiol Actions
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation and function of two related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Granulocyte colony stimulating factor (G-CSF) controls the production, differentiation and function of granulocytes. It has been shown to have a role in bone repair in animal models. G-CSF has been clinically approved for neutropenia treatment.
Physical form
Lyophilized from a PBS solution.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitution
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Kim JS
Oncology Reports, 34(1), 147-154 (2015)
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
Swift A
British Journal of Cancer, 71(5), 995-998 (1995)
Lian Cai et al.
PloS one, 15(3), e0230247-e0230247 (2020-03-18)
Granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine, belongs to the hematopoietic growth factor family. Recent studies have reported that G-CSF is a predictive biomarker of oocyte and embryo developmental competence in humans. The aim of our study was to determine
Effect of Granulocyte-Colony Stimulating Factor on Endothelial Cells and Osteoblasts.
Liu XL
BioMed Research International, 8485721-8485721 (2016)
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
Cytokine, 78, 69-78 (2016)
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