SRP6050
HB-EGF from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
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Synonym(s):
DTR, DTSF, HEGFL, Heparin-binding EGF-like growth factor, Proheparin-binding EGF-like growth factor
Recommended Products
biological source
mouse
recombinant
expressed in E. coli
Assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
potency
≥1x10^6 units/mg
mol wt
9.8 kDa
packaging
pkg of 10 μg
impurities
≤1 EU/μg
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... HBEGF(15200)
General description
HB-EGF (heparin-binding epidermal growth factor-like growth factor) belongs to the EGF family, and was first isolated as a secreted product from cultured human macrophages. It is produced as a precursor transmembrane protein (pro-HB-EGF), which is composed of EGF-like and heparin-binding domains. This precursor protein can be cleaved to produce a mature and soluble HB-EGF (sHB-EGF) form, and both these forms are active. It is expressed in various cell types including endothelial cells, epithelial cells, hematopoietic cells, and vascular smooth muscle cells.
Biochem/physiol Actions
HB-EGF (heparin-binding epidermal growth factor-like growth factor) functions as a mitogen and a chemotactic factor. Studies in experimental necrotizing enterocolitis (NEC) show that enteral administration of this factor confers protection to intestines from tissue injury, facilitates migration and proliferation of enterocytes, and maintains intestinal stem cell (ISC) viability. In endothelial nitric oxide synthase (eNOS)-knockout mice, a reduction in nitric oxide bioavailability results in elevated HB-EGF expression, which might be play an important role in progressive diabetic nephropathy. In mice with inactivated HB-EGF gene in the hippocampal area, there is reduced neurogenesis in the subgranular zone (SGZ) of the dentate gyrus. These mice also show suppression of PSD-95 (post synaptic density)/NMDA (N-methyl-D-aspartate)-receptor-NR1 (NMDA receptor)/NR2B subunits, and the subsequent NMDA receptor signaling.
Physical form
Lyophilized with no additives
Preparation Note
Centrifuge the vial prior to opening.
Reconstitution
It is recommended to reconstitute the lyophilized Mouse HB-EGF in sterile 18M-cm H?O not less than 100 μg/mL, which can then be further diluted to other aqueous solutions.
Other Notes
DLEGTDLNLF KVAFSSKPQG LATPSKERNG KKKKKGKGLG KKRDPCLRKY KDYCIHGECR YLQEFRTPSC KCLPGYHGHR CHGLTL.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression.
Miyazawa T, et al.
Kidney International, 84(6), 1176-1188 (2013)
Simon Melderis et al.
Journal of the American Society of Nephrology : JASN, 31(9), 1996-2012 (2020-07-04)
Recent studies have identified the EGF receptor (EGFR) ligand amphiregulin (AREG) as an important mediator of inflammatory diseases. Both pro- and anti-inflammatory functions have been described, but the role of AREG in GN remains unknown. The nephrotoxic nephritis model of
Heparin-binding EGF-like growth factor and enteric neural stem cell transplantation in the prevention of experimental necrotizing enterocolitis in mice.
Wei J, et al.
Pediatric Research, 78(1), 29-37 (2015)
NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice.
Sasaki K, et al.
Molecular Brain, 8(1) (2015)
Junichi Sugita et al.
Nature communications, 12(1), 1910-1910 (2021-03-28)
Cardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet medical need. Because right ventricular (RV) dysfunction increases the risk for sudden cardiac death, we examined responses to RV stress in mice. Among immune cells accumulated in
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