SRP6033
LBP human
recombinant, expressed in CHO cells, 90-95% (SDS-PAGE)
Synonym(s):
Lipopolysaccharide-binding protein
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
General description
Natural lipopolysaccharide binding protein (LBP) is a 58kDa glycoprotein produced in liver. This is a His-tagged protein. It is part of a family of lipid-binding proteins. The gene encoding this protein is localized on human chromosome 20q11.23.
Biochem/physiol Actions
Lipopolysaccharide binding protein (LBP) binds at lipid A of lipopolysaccharide (LPS) with high affinity (10-9M) and reduces the cellular LPS effects at CD14+ cells (IL1β, IL6, TNF-α). It acts as opsonin for GRAM negative cells, LPS, neutrophils and granulocytes. It transfers LPS to its receptor and this leads to an active inflammatory response. LBP also binds to LPS-coated erythrocytes. The protein has a role in innate immune responses against Gram-negative bacterial infections.
Physical form
Lyophilized from a concentrated protein solution (0.25 mg/ml) containing PBS, pH 7.1
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile distilled H?O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Robert S. Jack
CD14 in the Inflammatory Response null
Low levels of microbial translocation marker LBP are associated with sustained viral response after anti-HCV treatment in HIV-1/HCV co-infected patients.
Nystrom J
PLoS ONE, 10(3), e0118643-e0118643 (2015)
Copy number polymorphisms are not a common feature of innate immune genes.
Linzmeier RM and Ganz T
Genomics, 88(1), 122-126 (2006)
Serum LBP Is Associated with Insulin Resistance in Women with PCOS.
Zhu Q
PLoS ONE, 11(1), e0145337-e0145337 (2016)
Robert S. Jack
Inflammation & Allergy Drug Targets null
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