SRP6033
LBP human
recombinant, expressed in CHO cells, 90-95% (SDS-PAGE)
Synonym(s):
Lipopolysaccharide-binding protein
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
General description
Natural lipopolysaccharide binding protein (LBP) is a 58kDa glycoprotein produced in liver. This is a His-tagged protein. It is part of a family of lipid-binding proteins. The gene encoding this protein is localized on human chromosome 20q11.23.
Biochem/physiol Actions
Lipopolysaccharide binding protein (LBP) binds at lipid A of lipopolysaccharide (LPS) with high affinity (10-9M) and reduces the cellular LPS effects at CD14+ cells (IL1β, IL6, TNF-α). It acts as opsonin for GRAM negative cells, LPS, neutrophils and granulocytes. It transfers LPS to its receptor and this leads to an active inflammatory response. LBP also binds to LPS-coated erythrocytes. The protein has a role in innate immune responses against Gram-negative bacterial infections.
Physical form
Lyophilized from a concentrated protein solution (0.25 mg/ml) containing PBS, pH 7.1
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile distilled H?O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Low levels of microbial translocation marker LBP are associated with sustained viral response after anti-HCV treatment in HIV-1/HCV co-infected patients.
Nystrom J
PLoS ONE, 10(3), e0118643-e0118643 (2015)
Robert S. Jack
Inflammation & Allergy Drug Targets null
Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: Implications for a role of LBP in intracellular LPS-signaling.
Kopp F
Biochimica et Biophysica Acta, 1863(4), 660-672 (2016)
Serum LBP Is Associated with Insulin Resistance in Women with PCOS.
Zhu Q
PLoS ONE, 11(1), e0145337-e0145337 (2016)
Copy number polymorphisms are not a common feature of innate immune genes.
Linzmeier RM and Ganz T
Genomics, 88(1), 122-126 (2006)
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