SRP6027
UbcH5b human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
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Synonym(s):
UbcH
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biological source
human
recombinant
expressed in E. coli
Assay
≥95% (SDS-PAGE)
form
liquid
mol wt
17.0 kDa
packaging
pkg of 10 μg
concentration
~1.0 mg/mL
impurities
Endotoxin, tested
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... UB2D2(7322)
General description
E2 ubiquitin conjugating enzyme (UbcH5b), also called as ubiquitin conjugating enzyme E2D2 (UBE2D2), belongs to the active class of E2 ubiquitin conjugating enzymes, which also includes UbcH5A and UbcH5C. UbcH5b structure contains four N-terminal α-helices followed by four-stranded antiparallel β-sheet.
Biochem/physiol Actions
E2 ubiquitin conjugating enzyme (UbcH5b) is a vital component of E3 complex SCFβ-TrCP and it plays an important role in phospho-IκBα ubiquitination. UbcH5b along with others members of active classes of E2 enzymes plays a vital role in degradation of many regulatory and abnormal proteins, including important human transcription factors, such as p53, nuclear factor-κB (NF-κB) and c-Fos.
Physical form
Supplied at a concentration of 1.0 mg/ml in 20 mM Tris-HCl, pH 7.5, containing 0.5 mM DTT.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes.
Kim DW
Proceedings of the National Academy of Sciences of the USA, 102(39), 14046-14051 (2005)
Solution structure of the ubiquitin-conjugating enzyme UbcH5B.
Houben K
Journal of Molecular Biology, 344(2), 513-526 (2004)
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