SRP6005
FGF-21 murine
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
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Synonym(s):
FGF21, FGFL, Fibroblast growth factor 21
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biological source
mouse
recombinant
expressed in E. coli
Assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
20.1 kDa
packaging
pkg of 10 μg
impurities
Endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... FGF-21(56636)
General description
Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal methionine and having a molecular mass of 20.1kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence.The FGF-21 is purified by proprietary chromatographic techniques. FGF21 (fibroblast growth factor) is a hormonal factor that belongs to the FGF superfamily. It is generated by the liver. The gene encoding FGF21 is localized on mouse chromosome 7.
Biochem/physiol Actions
FGF21 (fibroblast growth factor) controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. FGF21 also possesses autocrine effects in white adipose tissue. The protein is also involved in bone loss and exhibits hepatoprotective properties. In addition, FGF21 is also implicated in lipid metabolism and energy balance. It plays a key role in controlling oxidative stress cell response.
Physical form
Lyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
The Journal of Biological Chemistry (2016)
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wang X, et al.
Cell Metabolism (2015)
Fibroblast growth factor 21 and its novel association with oxidative stress.
Gomez-S, et al.
Redox Biology (2017)
PPARa is a key regulator of hepatic FGF21
Lund?sen,L, et al.
Biochemical and Biophysical Research Communications, 360 (2007)
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
PLoS ONE (2016)
Articles
Fibroblast growth factors in cell culture and various growth factors for your research
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