SRP6005
FGF-21 murine
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
FGF21, FGFL, Fibroblast growth factor 21
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About This Item
Form:
lyophilized
Assay:
≥95% (HPLC), ≥95% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in E. coli
Mol wt:
20.1 kDa
biological source
mouse
recombinant
expressed in E. coli
assay
≥95% (HPLC), ≥95% (SDS-PAGE)
form
lyophilized
mol wt
20.1 kDa
packaging
pkg of 10 μg
impurities
Endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... FGF-21(56636)
General description
Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal methionine and having a molecular mass of 20.1kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence.The FGF-21 is purified by proprietary chromatographic techniques. FGF21 (fibroblast growth factor) is a hormonal factor that belongs to the FGF superfamily. It is generated by the liver. The gene encoding FGF21 is localized on mouse chromosome 7.
Biochem/physiol Actions
FGF21 (fibroblast growth factor) controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. FGF21 also possesses autocrine effects in white adipose tissue. The protein is also involved in bone loss and exhibits hepatoprotective properties. In addition, FGF21 is also implicated in lipid metabolism and energy balance. It plays a key role in controlling oxidative stress cell response.
Physical form
Lyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Fibroblast growth factor 21 in breast milk controls neonatal intestine function.
Gavalda-Navarro A, et al.
Scientific Reports, 5 (2015)
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
PLoS ONE (2016)
Fibroblast growth factor 21 and its novel association with oxidative stress.
Gomez-S, et al.
Redox Biology (2017)
PPARa is a key regulator of hepatic FGF21
Lund?sen,L, et al.
Biochemical and Biophysical Research Communications, 360 (2007)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
The Journal of Biological Chemistry (2016)
Articles
Fibroblast growth factors in cell culture and various growth factors for your research
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