SRP5321
EIF2AK1 (HRI), active, GST tagged human
PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
HCR, HRI, KIAA1369
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biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO®
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
9.6-14.4 nmol/min·mg
mol wt
~120 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... EIF2AK1(27102)
General description
Eukaryotic translation initiation factor 2-α kinase 1 (EIF2AK1) or HRI is a kinase that can be inactivated by hemin. The gene encoding this protein is localized on human chromosome 7p22.1.
Biochem/physiol Actions
Eukaryotic translation initiation factor 2-α kinase 1 (EIF2AK1) modulates protein synthesis. It acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-α. EIF2AK1 is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. It functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
The Host-Encoded Heme Regulated Inhibitor (HRI) Facilitates Virulence-Associated Activities of Bacterial Pathogens
Niraj Shrestha
PLoS ONE (2013)
Molecular characterisation of a recurrent, semi-cryptic RUNX1 translocation t(7;21) in myelodysplastic syndrome and acute myeloid leukaemia
Nicola Foster
British Journal of Haematology (2010)
HRI, a stress response eIF2a kinase, exhibits structural and functional stability at high temperature and alkaline conditions.
Bhavnani V
International Journal of Biological Macromolecules (2017)
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