SRP5316
RIPK3, active, GST tagged human
PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
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Synonym(s):
RIP3
Recommended Products
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO®
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
30-51 nmol/min·mg
mol wt
~96 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RIPK3(11035)
General description
Receptor interacting serine/threonine kinase 3 (RIPK3)/RIP3 is a serine/threonine kinase. It belongs to the receptor-interacting protein family. RIPK3 is characterized with a conserved amino-terminal kinase domain, which is necessary for necrosis. The gene RIPK3 is mapped to human chromosome 14. The encoded protein is composed of 518 amino acids.
Biochem/physiol Actions
Receptor interacting serine/threonine kinase 3 (RIPK3) activates necroptotic cell death and has a role in inflammatory signaling. The protein also functions in controlling viral infections, platelet functions, hemostasis and thrombosis. RIPK3 is highly expressed during cutaneous wound repair and also stimulates interleukin-1 β production.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis.
Zhang Y, et al.
Proceedings of the National Academy of Sciences of the USA, 114(11), 2964-2969 (2017)
Expression Profile and Tissue-Specific Distribution of the Receptor-Interacting Protein 3 in BALB/c Mice.
Wang Q, et al.
Biochemical Genetics, 54(4), 360-367 (2016)
Receptor-interacting protein kinase 3 deficiency delays cutaneous wound healing.
Godwin A, et al.
PLoS ONE, 10(10), e0140514-e0140514 (2015)
RIP3: a molecular switch for necrosis and inflammation.
Moriwaki K and Chan F K M
Genes & Development, 27(15), 1640-1649 (2013)
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation.
Daniels B P, et al.
Cell, 169(2), 301-313 (2017)
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