SRP4915
Vaspin human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
Synonym(s):
OL-64, SERPINA12, Serpin A12 precursor, Vaspin, Visceral adipose tissue- derived serine protease inhibitor, Visceral adipose-specific serpin
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized powder
Assay:
≥90% (HPLC), ≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~47.0 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥90% (HPLC), ≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
~47.0 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SPA12(145264)
General description
Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.
Biochem/physiol Actions
Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.
Physical form
1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Storage Class
13 - Non Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Vaspin: a novel adipokine, member of the family of serine protease inhibitors
Ekaterini Koiou
Aristotle University Medical Journal, 38.3, 7-18 (2011)
Vaspin as a Prognostic Marker in Patients with Acute Myocardial Infarction.
Zhang B
Heart, Lung & Circulation, 25(3), 257-264 (2016)
Feihong Yang et al.
Biochemical and biophysical research communications, 503(2), 501-507 (2018-05-08)
Visceral adipose tissue-derived serine protease inhibitor (vaspin), as a secretory adipokine, was reported to exert a protective role on insulin resistance. Recent studies showed that serum vaspin level was downregulated in patients with coronary artery disease. However, whether vaspin exerted
The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis.
Dimova R and Tankova T
BioMed Research International, 823481-823481 (2015)
S Kameshima et al.
Acta physiologica (Oxford, England), 216(2), 203-210 (2015-08-13)
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing activity originally identified in visceral adipose tissues of obesity-related type II diabetic rats. We previously showed that vaspin inhibits vascular cell migration and apoptosis as well as inflammatory
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