SRP4903
Adiponectin from rat
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
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Synonym(s):
ACDC, APM-1, Acrp30, AdipoQ, GBP-28
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
rat
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
lyophilized
mol wt
~30 kDa
packaging
pkg of 25 μg
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Adipoq(246253)
General description
Adiponectin (also called Acrp30, AdipoQ) is an adipocyte specific secreted protein that circulates in the plasma. It is induced during adipocyte differentiation and the secretion is stimulated by insulin.
Biochem/physiol Actions
Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia. Adiponectin regulates vascular function, sustains an anti-inflammatory environment and promotes angiogenesis.
Physical form
Lyophilized from a 0.2 μm filtered solution in 25 mM Tris, 0.15 M NaCl, pH 7.4 containing 50 μg of bovine serum albumin (BSA) per 1 μg of adiponectin.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Recontitute in PBS containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity.
Aprahamian TR
Metabolism and Disease, 62(12), 1730-1738 (2013)
Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice.
Wang F
PLoS ONE, 8(7), e68497-e68497 (2013)
Sergio García-Méndez et al.
Medicine, 94(26), e935-e935 (2015-07-02)
The aim of this study was to determine the levels of leptin (Lep) and adiponectin (AdipoQ) in patients with gout and its relationship with joint inflammatory data and/or with metabolic syndrome (MetS) variables, during 1 year follow-up.Forty-one patients (40 males)
Marcia J Abbott et al.
PloS one, 10(7), e0134290-e0134290 (2015-08-01)
Epidemiological studies show that high circulating levels of adiponectin are associated with low bone mineral density. The effect of adiponectin on skeletal homeostasis, on osteoblasts in particular, remains controversial. We investigated this issue using mice with adipocyte-specific over-expression of adiponectin
Articles
Lipid Induced Insulin Resistance
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