SRP4576
BMP-11 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
BMP 11, GDF11, Growth/Differentiation Factor-11, bone morphogenetic protein 11
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~32.6 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GDF11(10220)
General description
BMPs (bone morphogenetic proteins) belong to the transforming growth factor-β (TGF-β) superfamily of structurally related signaling proteins. BMP-11 is also known as growth differentiation factor 11 (GDF11). Recombinant human BMP-11 is a N-terminus His-tagged protein with a molecular weight of 32.6kDa (for homodimeric) and 16.2kDa (for monomeric) consisting of 136 amino acid polypeptide chains.
Biochem/physiol Actions
As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. They also enhance protein degradation and reduce skeletal muscle protein synthesis. BMP-11 may have a role in the development of the nervous system in mice. It acts as a modulator of development and differentiation. In mice, circulating levels of BMP-11 decrease with age.
Physical form
Lyophilized from 10 mM Sodium Citrate, pH 3.5.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 μg BSA per 1 μg of protein). This solution can then be diluted into other aqueous buffers.
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
GDF11 does not rescue aging-related pathological hypertrophy.
Smith SC
Circulation Research, 117(11), 926-932 (2015)
Clinical significance of growth differentiation factor 11 in colorectal cancer.
Yokoe T
International Journal of Oncology, 31(5), 1097-1101 (2007)
Growth differentiation factor 11 is an encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.
Vanbekbergen N
BMC Research Notes, 7, 766-766 (2014)
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