All Photos(1)
Synonym(s):
FABP1, FABPL, Fatty acid-binding protein 1 liver, L-FABP, Z-protein
UNSPSC Code:
12352200
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~19 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FABP1(2168)
General description
FABP1 (fatty acid-binding protein 1) belongs to the FABP family and localizes in the cytoplasm. The gene is mapped to human chromosome 2p12-q11.
Recombinant human FABP-1 was expressed from Escherichia coli and purified through proprietary method.
Recombinant human FABP-1 was expressed from Escherichia coli and purified through proprietary method.
Application
FABP1 human has been used in the FABP1 ELISA (enzyme-linked immunosorbent assay).
Biochem/physiol Actions
FABP1 (fatty acid-binding protein 1) mainly interacts with hydrophobic lipid ligands and is involved in intracellular fatty acid transport and utilization. FABP1 interacts with the plasma membrane to help in cholesterol transfer and also allows membrane microdomain changes. It controls lipid metabolism in the liver. Mutations in the gene are associated with the risk of type 2 diabetes, non-alcoholic fatty liver disease and homeostasis assessment index (HOMA-IR). The FABP1 gene is upregulated in liver, lung, gastric and colon cancers.
Physical form
Sterile filtered and Lyophilized without additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.
Shi J, et al.
PLoS ONE, 7, e48777-e48777 (2012)
Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein.
Wu YL, et al.
Journal of Virology, 90, 1729-1729 (2015)
Association of single-nucleotide polymorphisms rs2197076 and rs2241883 of FABP1 gene with polycystic ovary syndrome.
Xue H, et al.
Journal of Assisted Reproduction and Genetics, 33, 75-75 (2016)
Liver fatty acid-binding protein (L-FABP) promotes cellular angiogenesis and migration in hepatocellular carcinoma.
Ku CY, et al.
Oncotarget, 7, 18229-18229 (2016)
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