SRP4210
GRO/KC from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
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Synonym(s):
CXCL1, GRO α, GRO1, Growth-regulated α protein, NAP-3
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biological source
mouse
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
10-100 ng/mL
mol wt
~7.8 kDa
packaging
pkg of 20 μg
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Cxcl1(14825)
General description
Growth-regulated oncogenes (GRO)/keratinocyte chemoattractant (KC) belongs to the growing inflammatory protein superfamily. KC is characterized with four conserved cysteine residues with a CXC motif.
Mouse KC (also known as mouse GRO-α) belongs to the C-X-C family of chemokines. Mouse KC is a 7.8 kDa protein containing 72 amino acid residues.
Biochem/physiol Actions
Growth-regulated oncogenes (GRO)/keratinocyte chemoattractant (KC) plays a vital role in wound healing and inflammation. In rat, serum levels of GRO/KC can be used as a predictive biomarker for inhibitory effect of chemopreventive agents on esophageal carcinogenesis.
Physical form
Sterile filtered and then lyophilized without any additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1 mg/mL. This solution can be diluted into other aqueous buffers.
Regulatory Information
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.
Iida N A O K O, et al.
Molecular and Cellular Biochemistry, 10(10), 5596-5599 (1990)
Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue
Iida NAOKO and Grotendorst GR
Molecular Cell Biology, 10(10), 5596-5599 (1990)
Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats
Stoner GD, et al.
Pharmaceutical Research, 27(6), 1138-1145 (2010)
Aimalie L Hardaway et al.
Clinical & experimental metastasis, 32(4), 353-368 (2015-03-25)
Increased bone marrow adiposity is a common feature of advanced age, obesity and associated metabolic pathologies. Augmented numbers of marrow adipocytes positively correlate with dysregulated bone remodeling, also a well-established complication of metastatic disease. We have shown previously that marrow
Yuan Sun et al.
The journal of pain : official journal of the American Pain Society, 15(8), 856-866 (2014-06-03)
Chronic opioid consumption increases postoperative pain. Epigenetic changes related to chronic opioid use and surgical incision may be partially responsible for this enhancement. The CXCL1/CXCR2 signaling pathway, implicated in several pain models, is known to be epigenetically regulated via histone
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