SRP4066
FGF-21 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
FGF21, FGFL, Fibroblast growth factor 21
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Product Name
FGF-21 human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~19.5 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FGF21(26291)
Preparation Note
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Biochem/physiol Actions
FGF21 (fibroblast growth factor) is a hormonal factor which controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. It also possesses autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also involved in bone loss. FGF21 exhibits hepatoprotective properties.
General description
FGF21 (fibroblast growth factor) belongs to FGF superfamily. It is generated by the liver. The gene is mapped to human chromosome 19q13.33.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.
Physical form
Lyopohilized from 10 mM Tris, pH 7.5 plus 100 mM NaCl.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Novel locus including FGF21 is associated with dietary macronutrient intake.
Chu AY
Human Molecular Genetics, 22, 1895-1902 (2013)
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wang X
Cell Metabolism, 22, 811-824 (2015)
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
Coppage AL
PLoS ONE, 11, e0151269-e0151269 (2016)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
Dunshee DR
The Journal of Biological Chemistry, 291, 5986-5996 (2016)
Wen-Pin Huang et al.
Journal of cellular and molecular medicine, 26(8), 2451-2461 (2022-03-22)
Circulating endothelial progenitor cells (EPCs), which function in vascular repair, are the markers of endothelial dysfunction and vascular health. Fibroblast growth factor 21 (FGF21), a liver-secreted protein, plays a crucial role in glucose homeostasis and lipid metabolism. FGF21 has been reported
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