SRP3241
IL-13 Long Form from rat
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
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NC300 (Human) P600 (Murine), interleukin 13
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biological source
rat
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
≤5.0 ng/mL ED50
mol wt
12.3 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... IL13(116553)
Related Categories
General description
IL13 (interleukin 13) is a classic cytokine produced by Th2 (T-helper) cells. It was originally identified as an inflammatory cytokine production-inhibiting T-cell derived cytokine.
Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 11.9kDa protein consisting of 109 amino acid residues.
Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 11.9kDa protein consisting of 109 amino acid residues.
Biochem/physiol Actions
IL13 (interleukin 13) is up-regulated during parasitic infections, and participates in host′s protective immunity against Schistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes formation of liver granulomas in a CD4+ T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy.
Sequence
TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSIVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH
Physical form
Lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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IL-13 effector functions
Annual Review of Immunology, 21, 425-456 (2003)
Science (New York, N.Y.), 282(5397), 2258-2261 (1998-12-18)
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4(+) T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a
IL13 activates autophagy to regulate secretion in airway epithelial cells.
Autophagy, 12(2), 397-409 (2016)
An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.
PLoS ONE, 10(8), e0135360-e0135360 (2015)
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