SRP2085
BCL-10 human
recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
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Synonym(s):
CARMEN, CIPER, CLAP, c-E10, mE10
UNSPSC Code:
12352202
NACRES:
NA.26
Recommended Products
biological source
human
recombinant
expressed in insect cells
Assay
≥80% (SDS-PAGE)
form
frozen liquid
mol wt
~28 kDa
packaging
pkg of 6 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
250 μg/mL
color
clear
colorless
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BCL10(8915)
Biochem/physiol Actions
Bcl-10 is an intracellular signaling protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas. The human Bcl10 gene encodes a protein of 233 amino acids containing an N-terminal caspase recruitment domain (CARD) that mediates self-oligomerization and the C-terminal region of Bcl-10. Bcl 10 is expressed ubiquitously with high expression levels in lymphoid tissues and in the developing central nerve system. Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigen-receptor induced NF-kB activation and Bcl-10-initiated activation of NF-kB can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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S M Srinivasula et al.
The Journal of biological chemistry, 274(25), 17946-17954 (1999-06-11)
Molecules that regulate NF-kappaB activation play critical roles in apoptosis and inflammation. We describe the cloning of the cellular homolog of the equine herpesvirus-2 protein E10 and show that both proteins regulate apoptosis and NF-kappaB activation. These proteins were found
Q Zhang et al.
Nature genetics, 22(1), 63-68 (1999-05-13)
Mucosa-associated lymphoid tissue (MALT) lymphomas most frequently involve the gastrointestinal tract and are the most common subset of extranodal non-Hodgkin lymphoma (NHL). Here we describe overexpression of BCL10, a novel apoptotic signalling gene that encodes an amino-terminal caspase recruitment domain
T G Willis et al.
Cell, 96(1), 35-45 (1999-02-16)
MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase recruitment domain (CARD) homologous to
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