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Safety Information

SRP2057

Sigma-Aldrich

LXR β-ligand binding domain (211-461) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

LXR-b, LXRB, NER, NER-I, RIP15, UNR

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.26

biological source

human

recombinant

expressed in E. coli

Assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~30.9 kDa

packaging

pkg of 10 μg

concentration

700 μg/mL

color

clear colorless

NCBI accession no.

NM_007121

UniProt accession no.

P55055

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NR1H2(7376)

Biochem/physiol Actions

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXR β is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR α expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXR β expressed in livers of LXR α knockout mice does not compensate for the loss of LXR α. In addition, LXR β, but not LXR α, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXR β may have different biological functions.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
93085110
011271041

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  5. What is the composition of the buffer in Product SRP2057, LXR β-ligand binding domain (211-461) human?

    The buffer used in Product SRP2057, LXR ?-ligand binding domain (211-461) human, is 20 mM Tris-HCl, pH 8.0, 20% Glycerol, 100 mM KCl, 1 mM DTT, and 0.2 mM EDTA.

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D J Peet et al.
Current opinion in genetics & development, 8(5), 571-575 (1998-10-31)
The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has
R Apfel et al.
Molecular and cellular biology, 14(10), 7025-7035 (1994-10-01)
The steroid/hormone nuclear receptor superfamily comprises several subfamilies of receptors that interact with overlapping DNA sequences and/or related ligands. The thyroid/retinoid hormone receptor subfamily has recently attracted much interest because of the complex network of its receptor interactions. The retinoid
P J Willy et al.
Genes & development, 9(9), 1033-1045 (1995-05-01)
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily. LXR alpha shows a specific pattern of expression in visceral organs

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