SRP0430
PDE4A4B active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE)
Synonym(s):
DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥40% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Product Name
PDE4A4B active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE)
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥40% (SDS-PAGE)
form
aqueous solution
mol wt
124 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PDE4A(5141)
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
General description
Human PDE4A4B, also known as PDE4A isoform 1 (GenBank Accession No. NM_001111307) amino acids 2-end with N-terminal GST-tag, MW= 124 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Other Notes
One unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5?-AMP per min at 37°C.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Sullivan,M., et al.
Journal of Biochemistry, J. 333, 693-703 (1998)
Elaine Huston et al.
Journal of cell science, 119(Pt 18), 3799-3810 (2006-08-31)
The unique N-terminal regions of PDE4 cAMP-specific phosphodiesterases confer interaction with distinct signalling and scaffolding proteins. The PDE4A1 isoform is unique in being entirely membrane associated. Its N-terminal region is formed from two helices separated by a mobile hinge, where
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