SRP0427
PDE2A FLAG tag active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥88% (SDS-PAGE)
Synonym(s):
cGSPDE, phosphodiesterase 2A, cGMP-stimulated
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About This Item
UNSPSC Code:
12352200
Assay:
≥88% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥88% (SDS-PAGE)
form
aqueous solution
mol wt
106 kDa
packaging
pkg of 5 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PDE2A(5138)
General description
Human PDE2A (GenBank Accession No. NM_002599) amino-acids 2-941 with N-terminal FLAG-tag, MW=106 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.
Sergio E Martinez et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(20), 13260-13265 (2002-09-25)
Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of
Joachim Seybold et al.
Blood, 105(9), 3569-3576 (2005-01-15)
The pleiotropic cytokine tumor necrosis factor-alpha (TNF-alpha) and thrombin lead to increased endothelial permeability in sepsis. Numerous studies demonstrated the significance of intracellular cyclic nucleotides for the maintenance of endothelial barrier function. Actions of cyclic adenosine monophosphate (cAMP) and cyclic
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