SRP0424
Tankyrase 2 [849-1166] active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)
Synonym(s):
PARP5b, PARP5c, TNKS2, Tankyrase 2, poly(ADP-ribosyl)transferase 5b
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥30% (SDS-PAGE)
form
aqueous solution
mol wt
62 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TNKS2(80351)
General description
TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2), also known as PARP5B, tanykyrase-2, or TNKL (GenBank Accession No. NM_025235) amino acids 849-1166 (end) with N-terminal GST-tag, MW=62kDa, expressed in Sf9 cells via a Baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 Mm KCl, 4 mM glutathione, 20% glycerol, and 3 mM DTT.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Natalie Sidorova et al.
Cell and tissue research, 323(1), 137-145 (2005-09-10)
Tankyrase, which functions at telomeres and other cellular compartments, is thought to be a positive regulator of telomerase; its isoenzyme tankyrase 2 has been cloned as a putative cancer antigen. This pilot immunohistochemical study was designed to examine whether tumors
P G Kaminker et al.
The Journal of biological chemistry, 276(38), 35891-35899 (2001-07-17)
Tankyrase (TANK1) is a human telomere-associated poly(ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere length when overexpressed. Here we report characterization of a second human tankyrase, tankyrase 2 (TANK2), which can also interact with TRF1 but
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