SRP0406
Histone H2a full length human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
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Synonym(s):
H2AFQ, histone cluster 2, H2ac
UNSPSC Code:
12352200
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
aqueous solution
mol wt
14.8 kDa
packaging
pkg of 1 mg
storage condition
avoid repeated freeze/thaw cycles
concentration
1.2 mg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HIST2H2AC(8338)
General description
Histone cluster 2 H2A family member c (HIST2H2AC) is located on human chromosome 1q21. It is usually present in undifferentiated/proliferating cells. This canonical histone isoform has a protruding tail at both the N- and C-termini.
Histones make up the nucleosome, which is the fundamental unit of the chromatin. Each nucleosome consists of 146 base pairs of DNA which is wrapped around an octamer of four core histones H2A, H2B, H3 and H4. Histone cluster 2 H2A family member c (HIST2H2AC) has many variants. Human Histone 2A (GenBank Accession No. NM_033445) amino acids 2-130 (end) with N-terminal His-tag, MW = 14.8 kDa, expressed in an E. coli expression system.
Biochem/physiol Actions
Histone cluster 2 H2A family member c (HIST2H2AC) has a role in maintaining the structure of the chromatin.
Histone cluster 2 H2A family member c (HIST2H2AC) participates in multiple epigenetic regulations and carcinogenesis. It also participates in embryonic stem (ES) cell biology and regulates the expression of genes. It modulates proliferation and epithelial-mesenchymal transition in mammary epithelial and breast cancer cells. Hist2h2ac also controls epithelial differentiation.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome.
Ishibashi T
Biochemistry, 48(22), 5007-5017 (2009)
Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects.
Karaczyn AA
Annals of Clinical and Laboratory Science, 39(3), 251-262 (2009)
Wenlai Zhou et al.
The international journal of biochemistry & cell biology, 41(1), 12-15 (2008-10-22)
The precise molecular strategies that coordinate patterns of transcriptional response to specific signals is central for understanding normal development and disease. Precise control of transcriptional programs underlying metazoan development is modulated by enzymatically active coregulatory complexes, coupled with epigenetic strategies.
The histone H2A isoform Hist2h2ac is a novel regulator of proliferation and epithelial-mesenchymal transition in mammary epithelial and in breast cancer cells
Monteiro FL, et al.
Cancer Letters, 396, 42-52 (2017)
Mary Ann Osley
Briefings in functional genomics & proteomics, 5(3), 179-189 (2006-06-15)
Histone ubiquitylation has emerged as an important chromatin modification with roles in transcription and trans-histone methylation. In the past several years, there has been dramatic progress in the identification of factors that control ubiquitin attachment to the core histones H2A
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