SRP0393
EZH2/SUZ12/RbAp48 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥88% (SDS-PAGE)
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UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥88% (SDS-PAGE)
form
aqueous solution
mol wt
114 kDa (EZH2)
48 kDa (RbAP48)
87 kDa (SUZ12)
packaging
pkg of 20 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... EZH2(2146) , RBBP4(5928) , SUZ12(23512)
General description
Complex of human EZH2 (GenBank Accession No. NM_004456) amino acids 2-end with N-terminal His-GST tag, MW= 114kDa; human SUZ12 (GenBank Accession No. NM_015355) amino acids 1-end with N-terminal His-tag, MW = 87kDa, and human RbAp48 (GenBank Accession No. NM_005610) amino acids 2-end with N-terminal His-tag, MW= 48 kDa, co-expressed in Baculovirus expression system.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0, 110mM NaCl, 2.2 mM KCl, 18 mM Glutathione, 3mM DTT, and 20% glycerol.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain
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