SRP0387
EZH2 /EED/SUZ12/RbAp48/AEBP2 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥56% (SDS-PAGE)
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UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥56% (SDS-PAGE)
form
aqueous solution
mol wt
87 kDa (EZH2)
packaging
pkg of 20 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AEBP2(121536) , EED(8726) , EZH2(2146) , RBBP4(5928) , SUZ12(23512)
General description
Mutant version of EZH2 5- member complex with a Tyr-to-Asn mutation on amino acids 646 of the EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), amino acids 2-end (Y646N*) with N-terminal His-tag, MW= 86 kDa, human EED (GenBank Accession No. NM_003797) (amino acids 2-end) with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) (amino acids 2-end) with N-terminal His-tag, MW = 87 kDa, Human AEBP2 (GenBank Accession No. NM_153207) (amino acids 2-end) with N-terminal His-tag, MW= 53 kDa, and human RbAp48 (GenBank Accession No. NM_005610) (a-a 2- end) with N-terminal His-tag, MW = 48 kDa, co-expressed in Baculovirus expression system. *This mutation is often cited as Y641N in variant 3 GenBank Accession No. NM_001203247).
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain
Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
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