SRP0350
IGF-1R active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)
Synonym(s):
IGF1A, IGFI, insulin-like growth factor 1 (somatomedin C)
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥80% (SDS-PAGE)
form
aqueous solution
mol wt
72.3 kDa (46 + GST-tag)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.32 mg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IGF1(3479)
General description
Human IGFR1 (GenBank Accession No. NP_000875) , residues 930-1337 with N-terminal GST-fusion protein containing the 46 kDa cytoplasmic domain of the beta-subunit of the human Insulin-like Growth Factor-1 Receptor Kinase, MW=72.3 kDa, expressed in a Baculovirus expression system.
Application
Enzyme kinetics, autophosphorylation, and phosphorylation of target substrates.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
胰岛素激素类产品
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N. Tennagels, et al.
Biochemical and Biophysical Research Communications, 260, 7-7 (1999)
Shin-Taek Oh et al.
The American Journal of dermatopathology, 36(10), 807-811 (2014-07-08)
Insulin-like growth factor-1 receptor (IGF-1R) is a key regulator of cell transformation and controls the expression of genes that governs cell cycling and cell survival. The aim of this pilot study was to gain insight into the expression pattern of
K Baer et al.
Biochemistry, 40(47), 14268-14278 (2001-11-21)
To study the role of kinase dimerization in the activation of the insulin receptor (IR) and the insulin-like growth factor receptor-1 (IGF-1R), we have cloned, expressed, and purified monomeric and dimeric forms of the corresponding soluble kinase domains via the
Ying Xia et al.
American journal of translational research, 12(10), 6264-6276 (2020-11-17)
Full-thickness skin injury affects millions of people worldwide each year. Although bone marrow-derived mesenchymal stem cells (BM-MSCs) have been shown to promote cutaneous wound healing, they cannot functionally promote wound healing with the recovery of appendages such as hair follicles.
Michiko Shigyo et al.
Scientific reports, 5, 12055-12055 (2015-07-15)
Vimentin, an intermediate filament protein, is generally recognised as an intracellular protein. Previously, we reported that vimentin was secreted from astrocytes and promoted axonal growth. The effect of extracellular vimentin in neurons was a new finding, but its signalling pathway
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