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Safety Information

SRP0337

Sigma-Aldrich

Tyk2 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

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Synonym(s):
JTK1, tyrosine kinase 2
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

38 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

0.18 mg/mL

technique(s)

activity assay: suitable
inhibition assay: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TYK2(7297)

General description

Human Tyk2 (Tyrosine Kinase 2, also known as JTK1), (GenBank Accession No. NM_003331), amino acids 871-1187 (end) with N-terminal His-tag, MW=38 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Repr. 1B

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Partanen J, et al.
Proceedings of the National Academy of Sciences of the USA, 87, 8913-8917 (1991)
P Domanski et al.
FEBS letters, 374(3), 317-322 (1995-11-06)
The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms
I Firmbach-Kraft et al.
Oncogene, 5(9), 1329-1336 (1990-09-01)
We previously identified a novel protein tyrosine kinase gene, tyk2, by screening a human lymphoid cDNA library with a tyrosine kinase domain specific c-fms restriction fragment under low stringency hybridization conditions. We have now isolated and sequenced a full length

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