SRP0309
ATAT1 human
recombinant, expressed in E. coli, ≥55% (SDS-PAGE)
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Synonym(s):
MEC17, TAT, alpha tubulin acetyltransferase 1
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
Assay
≥55% (SDS-PAGE)
form
aqueous solution
mol wt
52 kDa
packaging
pkg of 50 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ATAT1(79969)
General description
Human α tubulin acetyltransferase 1, or ATAT1, (GenBank Accession No. NM_001031722 (var1)), amino acids 2 – 224 with N-terminal GST-tag, MW=52 kDa, expressed in an E. coli expression system.
The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes. αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms. It has also been identified in Tetrahymena, nematodes, zebrafish and mice.
The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes. αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms. It has also been identified in Tetrahymena, nematodes, zebrafish and mice.
Biochem/physiol Actions
ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylation, αTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules that are not aligned with acetyltransferase activity. αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling.
Oh S, et al.
Biochemical and Biophysical Research Communications, 482(1), Aug-A14 (2017)
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation.
Xu Z, et al.
Science, 356(6335), 328-332 (2017)
A Mec17-Myosin II effector axis coordinates microtubule acetylation and actin dynamics to control primary cilium biogenesis.
Rao Y, et al.
PLoS ONE, 9(12), e114087-e114087 (2014)
Structural basis of cofactor-mediated stabilization and substrate recognition of the ?-tubulin acetyltransferase ?TAT1.
Yuzawa S, et al.
The Biochemical Journal, 467(1), 103-113 (2015)
Tubulin acetylation: responsible enzymes, biological functions and human diseases.
Li L and Yang X J
Cellular and Molecular Life Sciences, 72(22), 4237-4255 (2015)
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