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SRE0053

Lysostaphin from Staphylococcus staphylolyticus

Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder

Synonym(s):

Glycyl-glycine Endopeptidase

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About This Item

CAS Number:
9011-93-2
UNSPSC Code:
12352204
NACRES:
NA.32
EC Number:
3.4.24.75 (BRENDA, IUBMB)
MDL number:
MFCD00131556

Key Documents

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Product Name

Lysostaphin from Staphylococcus staphylolyticus, Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder

biological source

bacterial (Staphylococcus sp.)

form

lyophilized powder

specific activity

≥500 units/mg protein

mol wt

26,926 Da

composition

protein, 50-70% biuret

packaging

pkg of (package size sold on basis of mg protein)

concentration

50—70% protein

suitability

suitable for microbiological tests

application(s)

diagnostic assay manufacturing

shipped in

wet ice

storage temp.

−20°C

Quality Level

300

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Biochem/physiol Actions

Lysostaphin has the ability to cleave both viable and heat-killed S. aureus cells. It is one of the major antibacterial agents for the staphylococci. Lysostaphin cleaves the cross-linking pentaglycine bridges in the cell walls of staphylococci. Thus it is considered as an antistaphylococcal therapeutic agent.
Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic.
pH Optimum for activity: ~7.5

General description

Lysostaphin is a glycylglycine endopeptidase. It is an important antibacterial enzyme.

Other Notes

One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH7.5 at 37°C in a 6.0ml reaction mixture.

wgk

WGK 3

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000477775
0000477775
0000161470
0000204873
026M4132V

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Lysostaphin disrupts Staphylococcus aureus and Staphylococcus epidermidis biofilms on artificial surfaces
Wu J A, et al.
Antimicrobial Agents and Chemotherapy, 47(11), 3407-3414 (2003)
Lysostaphin: a new bacteriolytic agent for the Staphylococcus
Schindler, Ch A and Schuhardt, VT
Proceedings of the National Academy of Sciences of the USA, 51(3), 414-421 (1964)

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