All Photos(1)
Synonym(s):
Dimethylethyl(3-hydroxyphenyl)ammonium chloride, Edrophone chloride, Ethyl(m-hydroxyphenyl)dimethylammonium chloride, N-Ethyl-3-hydroxy-N,N-dimethyl-benzenaminium chloride
Empirical Formula (Hill Notation):
C10H16NO·Cl
Quality Level
Assay
≥98% (HPLC)
form
powder
color
, Faint brown to very dark red brown
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
room temp
Biochem/physiol Actions
Bioavailable, acetylcholinesterase inhibitor with rapid onset and short duration of action.
Edrophonium chloride is a fast-acting, reversible and competitive inhibitor of acetylcholinesterase (AChE; Ki = 0.2, 0.2, and 0.4 μM in human red blood cells, purified calf forebrain, and octopus brain, respectively) with no effect on butyrylcholinesterase (BChE) activity. Edrophonium dispensing increases acetylcholine (ACh) levels in the neuromuscular junction to result in brief improvements in skeletal and muscular strength. Allosterically interacts with AChE-Serine103 and has a rapid onset of action occurring within 1 minute of administration and a short duration of action lasting 10 minutes with a very short half-life of 2–5 min (intravenous). Atropine, a competitive inhibitor of muscarinic receptors, is an ideal antidote for edrophonium.
Edrophonium chloride is a fast-acting, reversible and competitive inhibitor of acetylcholinesterase (AChE; Ki = 0.2, 0.2, and 0.4 μM in human red blood cells, purified calf forebrain, and octopus brain, respectively) with no effect on butyrylcholinesterase (BChE) activity. Edrophonium dispensing increases acetylcholine (ACh) levels in the neuromuscular junction to result in brief improvements in skeletal and muscular strength. Allosterically interacts with AChE-Serine103 and has a rapid onset of action occurring within 1 minute of administration and a short duration of action lasting 10 minutes with a very short half-life of 2–5 min (intravenous). Atropine, a competitive inhibitor of muscarinic receptors, is an ideal antidote for edrophonium.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Edrophonium
Abdullah Naji
StatPearls [Internet] (2024)
Joakim Holger Waage Brinch et al.
Acta anaesthesiologica Scandinavica, 63(5), 564-575 (2018-12-15)
Mivacurium is a short-acting non-depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase. The neuromuscular block (NMB) can be antagonized with cholinesterase inhibitors (CHEI), but the short duration of action of mivacurium questions the need. This systematic review evaluated if the
M L Andersson et al.
Anaesthesia, 74(4), 518-528 (2019-01-03)
Butyrylcholinesterase deficiency prolongs the effects of the drugs it degrades; succinylcholine and mivacurium. Existing literature on butyrylcholinesterase deficiency is dominated by genetic and biochemical studies. We searched MEDLINE, Embase, Web of Science and Biosis to systematically review the causes and
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