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Key Documents

Safety Information

SML3957

Sigma-Aldrich

OSS_128167

≥98% (HPLC)

Synonym(s):

5-[[3-[(2-Furanylcarbonyl)amino]benzoyl]amino]-2-hydroxybenzoic acid

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About This Item

Empirical Formula (Hill Notation):
C19H14N2O6
CAS Number:
Molecular Weight:
366.32
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

N(c2cc(ccc2)C(=O)Nc3cc(c(cc3)O)C(=O)O)C(=O)c1[o]ccc1

InChI

1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)

InChI key

HTJWLEGCECXGSQ-UHFFFAOYSA-N

Biochem/physiol Actions

eCll penetrant, potent and selective inhibitor of SIRT6.



OSS_128167 is a cell penetrant, potent and selective inhibitor of SIRT6 (Sirtuin 6) that exhibits anti-cancer, anti-inflammatory, and anti-viral properties. OSS_128167 inhibits HBV transcription and replication through upregulating peroxisome proliferator-activated receptors α (PPARα) expression.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Discovery of novel and selective SIRT6 inhibitors
Journal of Medicinal Chemistry, 57(11), 4796-4804 (2014)
Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6
Phytomedicine, 104, 154276-154276 (2022)
SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors ?
Frontiers in Pharmacology, 10, 1270-1270 (2019)

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