SML3908
SLU-PP-332
≥98% (HPLC)
Synonym(s):
(E)-4-Hydroxy-N′(naphthalen-2-ylmethylene)benzohydrazide, 4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide, ERR pan-Agonist 332, SR9861
About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
OC1=CC=C(C=C1)C(N/N=C/C2=CC3=C(C=C2)C=CC=C3)=O
InChI key
RNZIMBFHRXYRLL-XDHOZWIPSA-N
Biochem/physiol Actions
SLU-PP-332 is a non-toxic pan ERRα/β/γ (estrogen receptor-related receptors α/β/γ) agonist with significant ERRα activity (EC50 = 98, 230 & 430 nM against ERRα, ERRβ & ERγ) and acts as an exercise mimetic. SLU-PP-332 displays selectivity over ERα, ERβ and several other closely related nuclear receptors. It induces Ddit4 expression and enhances mitochondrial respiration in C2C12 myocytes (10 µM) and exercise endurance in mice (50 mg/kg bid, ip) in an ERRα-dependent manner.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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