Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

SML3900

Sigma-Aldrich

955, CDK9 PROTAC trifluoroacetate

≥98% (HPLC)

Synonym(s):

(E)-N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-(4-(2-(2,6-dimethoxy-4-(3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)phenoxy)ethyl)piperazin-1-yl)-2-oxoethyl)piperidine-4-carboxamide trifluoroacetate, PL-SNS-032 conjugate 955 trifluoroacetate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C41H53N7O8S2 · xC2HF3O2
Molecular Weight:
836.03 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

955 CDK9 PROTAC is a cell penetrant conjugate of the CDK9 inhibitor SNS-032 with new recruiter of the E3 ligase KEAP1 piperlongumine that potently degrades CDK9 in MOLT4 cells. Similarly, to THAL-SNS-032, 955 induces CDK10 degradation. 955 exhibits potent antiproliferative activity in several prostate cancer cell lines including LNCaP, 22RV1, PC3 and DU145 cells.

Caution

Hygroscopic

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Piperlongumine conjugates induce targeted protein degradation
Cell Chemical Biology, 30(2) (2023)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service