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Safety Information

SML3876

SHM115

new

≥98% (HPLC)

Synonym(s):

6-((Perfluorophenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyridin-5-ol, 6-[(2,3,4,5,6-Pentafluorophenyl)amino]-[1,2,5]oxadiazolo[3,4-b]pyridin-5(3H)-one

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About This Item

Empirical Formula (Hill Notation):
C11H3F5N4O2
CAS Number:
Molecular Weight:
318.16
UNSPSC Code:
12352200

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Orally active mitochondria uncoupler that increases the energy expenditure and lowers the body fat mass in vivo.
SHM115 is an orally active mitochondria uncoupler (EC50 = 17 μM; measured as oxygen consumption rate (OCR) increase in L6 rat myoblast cells) that increases the energy expenditure and lowers the body fat mass in two diet-induced obesity mouse models, including an obesity prevention model (130 mg/kg/d via chow) and an obesity reversal model (130 mg/kg/d via oral gavage).

Regulatory Information

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