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SML3863

Sigma-Aldrich

Tecovirimat

≥98% (HPLC)

Synonym(s):

4-Trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide, SIGA-246, ST-246, rel-N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C19H15F3N2O3
CAS Number:
869572-92-9
Molecular Weight:
376.33
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Antiviral with activity against orthopoxviruses such as cowpox and monkeypox and including smallpox
Tecovirimat (ST-246) is an antiviral with activity against orthopoxviruses such as cowpox and monkeypox and including smallpox. Tecovirimat inhibits the function of a major envelope protein required for the production of extracellar virus, prevented the virus from leaving the cell, and spreading within the body. FDA-approved for the treatment of human smallpox disease caused by Variola virus in adults and children.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000296123
0000296124
0000296123
0000296124
0000273611

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Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus
Viruses, 15(2), 570-570 (2023)
Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals
PLoS ONE, 8(2), e55808-e55808 (2013)
Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox)
Antimicrobial Agents and Chemotherapy, 57(12), 6246-6253 (2013)

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