All Photos(2)
Synonym(s):
1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine hydrochloride, 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide hydrochloride, 1-Phenethyl-biguanide hydrochloride, N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride
Empirical Formula (Hill Notation):
C10H15N5·HCl
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Phenformin is an orally available biguanide hypoglycemic drug. Phenformin can cause lactic acidosis thus it was withdrawn from most markets. Phenformin exhibits potent anticancer activity associated with AMPK activation and suppression of mTOR phosphorylation.
Caution
Hygroscopic
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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A review of phenformin, metformin, and imeglimin
Drug Development Research, 81(4), 390-401 (2020)
Rattanaporn Jaidee et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(9), 1681-1690 (2020-05-10)
Phenformin (Phen), a potent activator of AMPK, is effective against some resistant cancers. This study evaluated the inhibition of proliferation, migration, invasion, and angiogenesis by Phen in aggressive cancer cells and investigated the underlying mechanism of the inhibition. Cholangiocarcinoma (CCA)
Guanyi Liu et al.
Cells, 11(15) (2022-08-13)
The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis. Phenformin, a biguanide drug, has been
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