All Photos(1)
Synonym(s):
4,4a,5,5a,6,6a-Hexahydro-2-[4-[2-(4-methoxyphenyl)-2-oxoethoxy]phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione
Empirical Formula (Hill Notation):
C26H23NO5
CAS Number:
Molecular Weight:
429.46
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
MM0299 is a cell penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol. MM0299 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production
Cell Chemical Biology, 30(2), 214-229 (2023)
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