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SML3810

Sigma-Aldrich

p-Nitrobenzyl mesylate

≥98% (HPLC)

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Synonym(s):
4-Nitro-benzenemethanol Methanesulfonate, 4-Nitrobenzyl Mesylate, PNBM
Empirical Formula (Hill Notation):
C8H9NO5S
CAS Number:
39628-94-9
Molecular Weight:
231.23
MDL number:
MFCD25963099
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

p-Nitrobenzyl mesylate (PNBM) is a thiol-specific alkylating reagent for direct kinase substrate identification. p-Nitrobenzyl mesylate (PNBM) alkylates thiophosphorylated proteins to form thiophosphate ester epitopes that can be detected by thiophosphate-ester-specific antibody by immunoblotting, immunoprecipitation or immunoaffinity purification.

Caution

Hygroscopic

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PKC?/? inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
Molecular Cell, 81(21), 4509-4526 (2021)
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction
Cell Metabolism, 22(5), 907-921 (2015)
A semisynthetic epitope for kinase substrates
Nature Methods, 4(6), 511-516 (2007)

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