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Merck
CN

SML3767

AA-263

≥98% (HPLC)

Synonym(s):

2-Hydroxybenzaldehyde 2-(4-nitrophenyl)hydrazone, NSC 101540, Salicylaldehyde 4-nitrophenylhydrazone, o-Hydroxybenzaldehyde p-nitrophenylhydrazone

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About This Item

Empirical Formula (Hill Notation):
C13H11N3O3
CAS Number:
3155-24-6
Molecular Weight:
257.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00425292

Key Documents

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SMILES string

[N+](=O)([O-])c1ccc(cc1)N\N=C\c2c(cccc2)O

InChI

1S/C13H11N3O3/c17-13-4-2-1-3-10(13)9-14-15-11-5-7-12(8-6-11)16(18)19/h1-9,15,17H/b14-9+

InChI key

VQIJGQPVYQKSSH-NTEUORMPSA-N

assay

≥98% (HPLC)

form

powder

color

, Faint orange to Red

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

AA-263 is a cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z. AA-263 increases AAT neutrophil elastase (NE) inhibitory activity, while reducing polymer accumulation for the majority of AATD (alpha-1 antitrypsin (AAT) causes AAT deficiency) variants.
Cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z

wgk

WGK 3

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000305428
0000305431
0000305431
0000305428
0000278136

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Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
Cell Chemical Biology, 30(1) (2023)

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