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Safety Information

SML3763

Sigma-Aldrich

HSL-IN-1

≥97% (NMR)

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Synonym(s):
B-[5-Chloro-2-[[[6-[4-(trifluoromethyl)phenoxy]-3-pyridinyl]carbonyl]amino]phenyl]boronic acid
Empirical Formula (Hill Notation):
C19H13BClF3N2O4
CAS Number:
Molecular Weight:
436.58
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

Assay

≥97% (NMR)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

HSL-IN-1 is an orally available, potent, and selective inhibitor of Hormone-sensitive lipase (HSL) that exhibits an antilipolytic effect on rats.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production
Communications biology, 5(1), 1001-1001 (2022)
The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism in fish
The British Journal of Nutrition, 130(4), 588-603 (2023)
Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation
Bioorganic & Medicinal Chemistry, 25(7), 2234-2243 (2017)

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