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SML3740

Sigma-Aldrich

PY-60

≥98% (HPLC)

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Synonym(s):
5-Phenyl-N-[3-(2-thiazolyl)propyl]-3-isoxazolecarboxamide
Empirical Formula (Hill Notation):
C16H15N3O2S
CAS Number:
Molecular Weight:
313.37
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

PY-60 is a potent and specific activator of the transcriptional coactivator Yes-associated protein 1 (YAP) signaling. It stimulates YAP-dependent expansion of epidermal keratinocytes in mouse. PY-60 binds directly to annexin A2 (ANXA2) causing its liberation and YAP activation.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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