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Key Documents

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SML3687

Sigma-Aldrich

TL8-506

≥98% (HPLC)

Synonym(s):

(1E,4E)-Ethyl 2-amino-8-(3-cyanophenyl)-3H-1-benzo[b]azepine-4-carboxylate, Ethyl 2-amino-8-(3-cyanophenyl)-3H-1-benzazepine-4-carboxylate, TL 8-506, TLR 8-506

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4 L
CN¥2,166.96

CN¥2,166.96

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4 L
CN¥2,166.96

About This Item

Empirical Formula (Hill Notation):
C20H17N3O2
CAS Number:
1268163-15-0
Molecular Weight:
331.37
MDL number:
MFCD28359121
UNSPSC Code:
12352200

CN¥2,166.96

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

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room temp

storage temp.

10-30°C

assay

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assay

-

assay

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assay

-

Quality Level

200

Quality Level

200

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mp

>300 °C

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>300 °C

agency

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agency

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Biochem/physiol Actions

Motolimod (VTX-2337) analog and a toll-like receptor 8 (TLR8)-selective agonist with stronger activity than resiquimod (R848) and CL075 (3M002).
TL8-506 is a motolimod (VTX-2337) analog and a benzoazepine class toll-like receptor 8 (TLR8)-selective agonist. TL8-506 is commonly employed in the concentration range from 0.1 μg/mL to 1 μg/mL for stimulating cell surface TLR8 in cultures and is reported to be a stronger TLR8 ligand than the imidazoquinoline (IMDQ) derivatives (IQDs) resiquimod (R848) and CL075 (3M002).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000243962
    0000239692
    0000243962
    0000243963
    0000239692

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    Bin Tang et al.
    Parasitology research, 119(8), 2505-2510 (2020-06-15)
    Human trichinellosis is acquired by eating raw or undercooked meats carrying muscle larvae of Trichinella spp. Toll-like receptors (TLRs) are essential components of the innate immune system. However, little is known about the potential application of TLR agonists for immunotherapy
    Jennifer Nelson et al.
    Science advances, 6(26), eaaz6893-eaaz6893 (2020-07-09)
    Messenger RNA (mRNA) represents an attractive therapeutic modality for potentially a wide range of clinical indications but requires uridine chemistry modification and/or tuning of the production process to prevent activation of cellular innate immune sensors and a concomitant reduction in
    Ruben Serrano et al.
    Cells, 9(3) (2020-03-19)
    Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4
    Jahnavi Aluri et al.
    Blood, 137(18), 2450-2462 (2021-01-30)
    Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the human immune response. We
    Kamil Krawczynski et al.
    Journal of cell science, 134(5) (2020-10-24)
    The function of microRNAs (miRNAs) can be cell autonomous or communicated to other cell types and has been implicated in diverse biological processes. We previously demonstrated that miR-517a-3p (miR-517a), a highly expressed member of the chromosome 19 miRNA cluster (C19MC)
    View All Related Papers

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