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SML3653

Sigma-Aldrich

Triptorelin pamoate

≥95% (HPLC)

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Synonym(s):
Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 pamoate salt, Triptorelin ebonate, [D-Trp6]-LH-RH pamoate
Linear Formula:
C64H82N18O13·xC23H16O6
CAS Number:
124508-66-3
UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

100

Assay

≥95% (HPLC)

form

(Powder or lyophilized powder or film)

mol wt

1311.45 g/mol

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

SMILES string

OC1=C(CC2=C(O)C(C(O)=O)=CC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1C(O)=O.O=C([C@H](CC5)NC5=O)N[C@@H](CC6=CN=CN6)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C(N[C@@H](CO)C(N[C@@H](CC9=CC=C(O)C=C9)C(N[C@H](CC%10=CNC%11=C%10C=CC=C%11)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N%12[C@H](

Biochem/physiol Actions

Triptorelin pamoate is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). It is used clinically to treat prostate cancer and precocious puberty in boys and girls.

Caution

Hygroscopic

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Hazard Classifications

Repr. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Giulia Marvaso et al.
Anticancer research, 38(5), 3139-3143 (2018-05-02)
Patients with locally advanced prostate cancer are generally treated with radiotherapy (RT) which can be combined with hormonal therapy. RT plus monotherapy with luteinizing hormone-releasing hormone (LHRH) analog triptorelin was compared to RT plus total androgen block (TAB). A retrospective
Delphine Zenaty et al.
Hormone research in paediatrics, 86(3), 188-195 (2016-11-02)
To evaluate the efficacy and safety of a triptorelin pamoate (11.25 mg) 3-month formulation in the management of central precocious puberty (CPP) (TP Study) and to retrospectively compare it with a triptorelin acetate (11.25 mg) 3-month formulation (TA Study). We
Triptorelin relieves lower urinary tract symptoms in Chinese advanced prostate cancer patients: a multicenter, non-interventional, prospective study
BMC Urology, 18(1), 23-23 (2018)

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