SML3651
Deschloroclozapine
≥98% (HPLC)
Synonym(s):
11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, DCZ
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About This Item
Empirical Formula (Hill Notation):
C18H20N4
CAS Number:
Molecular Weight:
292.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Deschloroclozapine (DCZ) is a potent and selective DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) agonist (hM3Dq/hM4Di Ki = 6.3/4.2 nM vs hM3/hM4 Ki = 230/210 nM; hM3Dq/hM4Di EC50 = 130/81 nM by celluar BRET assays) with much greater potency than CNO and C21. DCZ selectively stimulates DREADDs, but not non-DREADDs, cells (Ca2+ EC50 = 2.3 nM/hM3Dq, cAMP IC50 = 0.0048 nM/hM4Di, β-arrestin recruitment EC50 = 0.63 nM/hM3Dq & 0.048 nM/hM4Di). DCZ enhances neuronal activity in hM3Dq mice (1 μg/kg i.p.) & monkeys (1-3 μg/kg i.v.) and induces spatial working memory deficits in hM4Di monkeys (100 μg/kg i.m.) in vivo.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Nicholas A Upright et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(11), 1793-1798 (2020-03-21)
The most common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscarinic acetylcholine receptor that is insensitive to acetylcholine. It is crucial in studies using these systems to
Loris L Ferrari et al.
Journal of neuroscience methods, 380, 109679-109679 (2022-08-02)
Chemogenetics is a powerful tool to study the role of specific neuronal populations in physiology and diseases. Of particular interest, in mice, acute and specific activation of parafacial zone (PZ) GABAergic neurons expressing the Designer Receptors Activated by Designer Drugs
Yuji Nagai et al.
Nature neuroscience, 23(9), 1157-1167 (2020-07-08)
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with clozapine-N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities and
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